Everything you Need to Know About Ecdysterone

Everything you Need to Know About Ecdysterone

Several plants, including spinach and quinoa, contain ecdysterone, which is a natural steroid. Phytoecdysteroids are technically phytoestrogens.

It is important to remember that steroids are organic compounds, not necessarily synthetic anabolic steroids, which are variations of the male sex hormone testosterone).

What Is Ecdysterone?

The most important question is what is ecdysterone? So let’s find out..

The ecdysteroid compound ecdysterone is naturally found in some insects and plants, including spinach. The main purpose of taking it in supplement form is to improve athletic performance and muscle gain.

Research suggests that it can help people build lean muscle mass, and increase strength and power more easily within two to three months.

Ecdysterone supplements go by several other names, including spinach extract, 20-hydroxy-ecdysterone, beta-ecdysterone, and alfa-ecdysterone.

Benefits and Uses of Ecdysterone

It has only recently become more widely available as a supplement, so reliable studies on this compound are limited. According to research and testimonials, here are some of its potential benefits:

  1. Muscle Building

Accumulating muscle mass might be easier with ecdysterone, which is believed to help increase protein synthesis.

It has been shown that it has a high “anabolic ratio,” which means it can increase:

  • The process of forming muscle cells 
  • protein synthesis from amino acids
  • red blood cell production
  • bone remodelling and growth

The estrogen receptor (ER) binding properties of ecdysterone are thought to mediate its anabolic effects. Regulation of skeletal muscle growth and regeneration is mediated by ERB signalling, modulating immune function.

Furthermore, ecdysterone enhances muscle protein synthesis by affecting PI3K/Akt signalling pathways.

  1. Athletic Performance

The benefits of ecdysterone supplements include building muscle, reducing fatigue, and speeding up recovery. Beta-ecdysone was once referred to as the “Russian secret” because Russian athletes allegedly used it.

The researchers recommended that ecdysterone be added to list of prohibited steroid compounds among competitive athletes because it was found to be so effective.

  1. Improves Insulin Sensitivity

Although more research is needed on this topic, at least one animal study suggests that ecdysterone supplements may support metabolic health, including preventing insulin resistance, hyperglycemia (high blood sugar, which is related to type 2 diabetes) and obesity.

Researchers found that oral administration of ecdysterone at doses of 10 milligrams per kilogram of body weight for 13 weeks alleviated obesity and insulin resistance in rats. Supplementation prevented significant increases in body weight gain and body fat mass compared with non-treated rats that were fed a high-fat diet.

In the group given ecdysterone, plasma insulin levels and glucose tolerance were also significantly lowered.

  1. Supports Immune Function

Ecdysteroids may have some adaptogenic effects that can help the body cope with stress and pathogens. Among the potential ways that this compound could support homeostasis and immunity are:

  • Increasing red blood cell number
  • Improving the quality of sleep
  • Improving tolerance to thermal stress
  • Providing support for cardiac function and circulation
  • Stimulating bone growth
  • Having anti-inflammatory and antioxidant effects

Risks and Side Effects of Ecdysterone

As long as it’s not misused, ecdysterone is generally considered to be safe. While it’s currently not banned or treated like a steroid in major countries like the U.S. and Canada. According to the 2021 Monitoring Program, WADA intends to gather more information about this substance to determine if it should be prohibited.

According to one of the most reliable studies, taking it as a supplement did not result in liver or kidney toxicity. Compared to other steroid drugs, it seems to be less likely to cause side effects, such as changes in appetite, sleep, mood, and libido.

Purchasing an ecdysterone supplement from a reputable seller will prevent potential side effects, or simply save you money. Studies suggest that combining ecdysterone (or 20-hydroxyecdysone) with cyclodextrin can improve absorption of this compound, so look for supplements that combine these two ingredients.


In terms of the dosage of beta-ecdysterone, it differs depending on the individual who is taking the supplement. Since there is no standard dosage recommendation for currently available products, it’s important to read the product’s instructions carefully before use.

Several studies have shown that low doses between 12 milligrams per day and 45 milligrams per day can be taken safely for about ten weeks. When coupled with consistent strength training, this amount of protein is enough to promote gains in muscle mass.

If it is combined with cyclodextrin, it will help with absorption and may result in even greater benefits.

Some people report good results when they take much higher doses, up to 500 mg to 1,000 mg per day. It is important to remember that higher dosages may lead to more improvements in muscle mass and strength, but they are also associated with more risk.

Generally speaking, it’s best to start with a lower dose and see how you react, then increase as needed.


Among the most effective natural supplements for building muscle and strength, it’s growing in popularity.

That’s because it’s extremely effective, and it’s not uncommon to gain up to 10 pounds in a single cycle. It’s not just good for putting on size, but it’s also good for strength and recovery.

Amy Jackson